Deepfakes & disinformation How research helps fight manipulation 4 2 | 2 Bring on the water! Improving management of this vital resource Dr. Marius Mohr, Fraunhofer IGB Fraunhofer start-ups From one-person company to success with laser technology “We take the situation seriously!” Interview with Nancy Faeser, the German Federal Minister of the Interior

2 | 24 Fraunhofer magazine Editorial Minimizing risk, maximizing opportunities By Prof. Holger Hanselka New reports come pouring in every day. Artificial intelli- gence (AI) creates whole new opportunities for manipulat- ing the masses, which is especially alarming at a time when there are crucial elections coming up in countries like Germany and the U.S. German federal interior minis- ter Nancy Faeser also warns about the challenges involved. “The perpetrators are getting more and more professional,” she says in an interview with the Fraunhofer magazine (see page 46). That’s the political aspect. And what about the economic side? AI costs jobs. AI creates jobs. AI is revo- lutionizing our working world. Anything and everything seems to be possible. And like anytime when so much seems to be in flux, when disruptive and radical change is afoot, both hopes and fears are on the rise. Even amid all the concerns about risks, which are certainly justified, I personally believe the opportunities clearly out- weigh them. Even just by itself, AI-supported robotics will enhance Germany’s competitiveness as a hub of industry. AI will unlock whole new potential in the fight against cancer. AI will boost the efficiency of our energy system — and thus also support the energy transition. DZ Bank just recently published the results of a representative survey of the man- agement of 1,000 medium-sized companies. According to their findings, managing directors expect the use of genera- tive AI to help with obtaining information (30 percent) and with creativity (24 percent). And with one of their biggest problems, too: Nearly 60 percent of respondents say genera- tive AI will help them cope with bureaucratic burdens. Fraunhofer takes a position on this, too. In our latest posi- tion paper on generative AI, we stress how crucial it will be to implement the EU Artificial Intelligence Act quickly, with little bureaucracy, and with foresight. It will also be critically important to support innovation partnerships between industry, medium-sized businesses, and applied research. This is the only way we will move generative AI into industrial application at the necessary speed and as widely as needed. According to a recent study by the Ger- man Economic Institute (IW) in Cologne, generative AI applications will generate an additional 330 billion euros Prof. Holger Hanselka in value creation for the German economy. As we can see, overcoming our fears will be worthwhile. We will benefit if we master the risks. We will gain the opportunity to strengthen Germany’s technological sovereignty as a hub of industry in the long term, together with our European allies. The Fraunhofer-Gesellschaft will be a helpful partner along the way, especially for medium-sized businesses. Fraunhofer got involved with the development of generative AI very early on and has invested more than 50 million euros of equity in building expertise in this field. Through its insti- tutes, the Fraunhofer-Gesellschaft is involved in developing large sovereign applied AI models such as OpenGPT-X and EuroLingua. To give just one of many examples, the Fraun- hofer Institute for Applied Information Technology FIT is involved in multiple projects with industry focusing on introducing AI in real-world practice at businesses. These kinds of connections in application and forms of collabora- tion like this help companies to minimize risks and maxi- mize opportunities. Fraunhofer is glad to help them along the way with its research experience. Let’s all continue to work together on innovative solutions across industry and the medium-sized business and research sectors. For pros- perity. For society. For our future. Sincerely, Prof. Holger Hanselka President of the Fraunhofer-Gesellschaft back to page 1 3 r e i e m r e b O n a f e t S / r e f o h n u a r F : o t o h P

27 A breath of fresh air UV light keeps chicken coops germ-free 28 A voice from the business world Oliver Zipse, CEO of BMW AG 30 Taking a “bite” out of bacteria — preventing resistance Fighting gum disease without antibiotics 35 Knowledge relay, episode 12 Upheaval and new directions: How will AI change our world, Prof. Hanselka? 50 Faster diagnosis of rare diseases How AI can shorten the diagnostic journey and reduce suffering for patients 52 Cars made without new materials (almost) A team of researchers works on recyclable EVs 60 Let there be light! How can more sunlight be brought into the office? 56 Smart spy Smart sensors provide information on the condition of materials 54 Charging during breaks 58 Fraunhofer worldwide Fast-charging infrastructure for electric trucks on long-haul trips 60 Let there be light! Using natural light more effectively indoors, without glare 62 Photo & Fraunhofer Sticking like a gecko 62 High five! Geckos have superpowers — as researchers are learning from the scaly lizards. 64 Successful with laser technology 84 Telltale signs A Fraunhofer spin-off has been successfully supporting companies with laser hardening for 25 years How can hypersonic weapons be detected and tracked accurately? 87 Fraunhofer on the road 66 Ready for the 21st century How well prepared are today’s primary and secondary school students for the working world of tomorrow? 68 “An intestine on 16 legs” Tobacco hornworms help to study Crohn’s disease and other medical conditions 70 Healing fractures with glass How to heal breaks faster and more reliably back to page 1 Just 8 percent of Germany’s rivers and streams are healthy, as the German Environment Agency (UBA) found in 2021. The European Water Framework Directive requires all bodies of water to be in good environmental condition by 2027. We are far from meeting that goal, as the UBA’s most recent Environmental Monitor shows. 8 2 | 24 Fraunhofer magazine i l e r u t c i p n a p / g r e b e g g ü R s i d r o h T 30 Goodbye, bleeding gums! New prophylactic paste effectively prevents gum disease , k c o t S e b o d A / a y a k s d e s n o S , s e g a m 72 RoboKeeper — the world’s fastest goalie A robot from Fraunhofer IML competes with Manuel Neuer 74 Full speed ahead! Scientists have devised tiny sub- marines to transport medications right to where they are needed inside the human body 76 Research prizes The winners, the projects: four pathbreaking developments i s u i t i r u a m / 1 6 d n e t s e W / n o s f f e s o J , T I S r e f o h n u a r F / i n u a r B r e t e D i , f i i a L / n e P s a e r d n A ; h c s r i H r e v n E : s o t o h p r e v o c k c a b d n a t n o r F a . t r a a e s h t i w d e t i d e , o t o h p k c o t s i , f i a l / h c i l ü J r e t e P , h c s r i H r e v n E : s o t o h p t n e t n o C 5

2 | 24 Fraunhofer magazine More safety on the road Researchers at the Fraunhofer Institute for Applied Optics and Precision Engineering IOF have devised a blinker that displays the desired direction of travel not just on the vehicle itself, but on the road surface as well. To do this, it projects a dynamic sequence of arrow symbols at a light intensity of over 7,000 Lux onto the road surface, ensuring good visibility even in daylight. The two-sided microlens array (MLA) consists of an array of arrow-shaped “lenslets” on the light input side and smaller square ones on the output side. By illumi- nating the MLA at different angles, light paths are steered between certain combinations of input and output lens- lets. This design approach makes it possible to generate arrow symbols in different positions with a single pro- jector system, which simplifies installation and reduces costs and space requirements. The two-sided microlens arrays are produced using grayscale lithography and then replicated as polymer- on-glass tandem arrays. The combination of polymer and glass permits precision control of optical properties because the polymer material can be applied to the glass surface and shaped on a targeted basis. The projecting blinker is just 35 x 35 x 55 millimeters in size, but has high light intensity. back to page 1 7 The German Federal Statistical Office predicts that the number of people requiring nursing care will increase by about 37 percent between now and 2055. Artificial intelligence supports long-term care The Fraunhofer Institute for Industrial Mathematics ITWM is developing and testing a knowledge-based, data-driven assistance system for professional pro- cess design in long-term care in collaboration with partners as part of the ViKI pro project. The AI-based system allows specialists to identify individual care needs and plan appropriate measures using digi- talized specialist knowledge. The documentation of the care measures implemented in the web applica- tion also helps to accumulate practical knowledge that can be used for future planning. The quality of the data sets used is key here. Each care case is therefore entered with a comprehensive and detailed medical history including a risk matrix, considering numerous factors such as whether the patient is bedridden, able to take care of themselves, overweight, depressed, and so on. The system then uses artificial intelligence to suggest suitable care measures, which care planners then choose from based on their experience. The goal of ViKI is to help improve the quality of inpatient care and conserve resources, which are in short supply. F O I r e f o h n u a r F , ) 3 ( o t o h p k c o t S i m o r f s o t o h p l l a / i a m a P t n a n a s s a n a M y h p a r g o t o h P e , l y t s e f i L y t i C e l t t i L , l g e o s : s o t o h P

Editorial notes Fraunhofer. The magazine for research, technology and innovation ISSN 1868-3428 (print edition) ISSN 1868-3436 (online edition) Published by: Fraunhofer-Gesellschaft Hansastrasse 27c, 80686 Munich, Germany Editorial address as above Phone +49 89 1205-1301 magazin@zv.fraunhofer.de https://s.fhg.de/magazine-en Free subscription: Phone +49 89 1205-1301 publikationen@fraunhofer.de Editorial team: Monika Landgraf (responsible for content), Josef Oskar Seitz (editor-in-chief), Dr. Sonja Endres, Beate Strobel Editorial assistants: Dr. Janine van Ackeren, Mandy Bartel, Sirka Henning, Andrea Kaufmann, Manuel Montefalcone, Lisa Scher- baum, Kathrin Schwarze-Reiter, Franziska Sell, Stefanie Smuda, Mehmet Toprak, Anja Wächter, Yvonne Weiß, Ulla Wolfshöfer Layout and lithography: Vierthaler & Braun Cover image and cover story photography: Enver Hirsch Printed by: Kolibri Druck, Nuremberg © Fraunhofer-Gesellschaft e. V. Munich 2024 Find Fraunhofer on social media: @Fraunhofer www.facebook.com/ fraunhoferde www.instagram.com/ fraunhofergesellschaft www.linkedin.com/company/ fraunhofer-gesellschaft www.youtube.com/ fraunhofer 2 | 24 Fraunhofer magazine Nitrosamines can form in meat at tempera- tures of 130 degrees Celsius and above. Not always harmful to health Barbecue season is in full swing — bringing with it warnings about nitrosamines in charred meat and meat products. A recent study by Fraunhofer ITEM shows that not all of these items are dangerous. A mines are present not only in foods, but also in many medica- tions, as they are highly effective in pharmacological terms. When they encounter nitrites from food in the acidic environment of the stomach, nitrosamines can form. These compounds are believed to be carcinogenic and mutagenic. A team from the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and other partners worked on behalf of the European Medicines Agency (EMA) to study which active substances pose an elevated risk. Dr. Sylvia Escher, head of the In-silico Toxicology department, com- ments: “Luckily, relevant amounts of nitrosamines developed under realistic physiological conditions in the case of only four of the twelve substances studied.” Further studies of cell cultures also allowed the team of researchers to show that not all nitrosamines have mutagenic effects — far from it, in fact. “Larger nitrosamines that have a more complex structure are less active, which makes them less of a concern,” explains Dr. Christina Ziemann, head of the Genetic Toxicology working group. The results corroborate a new evalua- tion system used by the EMA, which divides nitrosamines into five categories based on certain structural features, from highly potent to least concern. Highly sensitive in-vitro testing systems adapted to nitro- samines should also help to identify crit- ical nitrosamines that require further study early on, thereby accelerating the approval of medications on the whole. back to page 1 9 ) 3 ( o t o h p k c o t S i m o r f s o t o h p l l i a / c i g Z n e z a r D , s a t o n r e B s i t y R , . C d r a n o e L : s o t o h P

2 | 24 Fraunhofer magazine Staying afloat: Dr. Lukas Kriem looks for ways to use wastewater more effectively in his work at Fraunhofer IGB. For Fraunhofer magazine, he decided to take a dip in a swimming pool instead. back to page 1 11

2 | 24 Fraunhofer magazine “Our approach is to link isolated solutions together into a single system to enhance the efficiency of the drinking water supply.” Susanne Liane Buck, Fraunhofer IAO Building bridges: Buck, a sociologist, plans to optimize water manage- ment in a local area in Bremen by connecting all stakeholders together. back to page 1 13

2 | 24 Fraunhofer magazine supply line inside buildings to provide “second-class water” for things like water- ing plants: “Once you increase the num- ber of supply networks, the risk of improper connections rises, and that’s something we can’t have when it comes to drinking water. Even the slightest doubt about quality will be enough to turn people against using the drinking water that comes from the tap and send them running to buy water in plastic or glass bottles instead, which is even less sus- tainable.” Projects like InDigWa can also help main- tain water quality, however. “Increasingly long periods of heat also bring hygiene problems with them, such as a rising risk of Legionella bacteria in the water,” Buck explains. Continuous data collection is likely to make it possible for munici- palities to monitor these factors more efficiently going forward. For consumers, reports on their own consumption through an app or in other forms could also come as a wake-up call of sorts. After all, who among us knows how much water they use to shower in the morning or water the plants? Putting a figure to everyday usage like this and communicating it back to the consumer, whether that means a private individual or a company, is also the goal of the CrowdWater project funded by the German Federal Ministry for Economic Affairs and Climate Action (BMWK): Under the over- all coordination of the Fraunhofer Institute for Applied Information Technology FIT, selected households and businesses are being equipped with smart meters and connected together to create a “living lab” that surveys water use in different sectors under real-world conditions. “Our goal is to develop a decentralized data platform that can be used to measure water consumption in connection with specific events and then report it back to the consumer,” explains Dr. Marc Jentsch, an IT expert at Fraunhofer FIT. “After that, we plan to analyze the degree to which knowing their usage data changes people’s consumption habits and what incentives can spur sustainable water use.” Right now, Jentsch and his team are still looking for private households and manufacturing companies in the districts of Troisdorf, Kirchen (Sieg) and Hennef that are inter- ested in participating in the living lab (for more info, visit crowdwater.info). A sports school is already on board. To date, the school only has a single central meter for water consumption, so there are no details about how much water is being used for the swimming pool, showers, or watering the green space. Jentsch explains: “The school is hoping to use smart sensors to monitor water use by different areas in real time in the future.” As for the utility companies, they see huge potential for optimization in detecting leaks. “CrowdWater will help us Worldwide water consumption sextupled from 1930 to 2000 — as the global population tripled. (Source: German Federal Agency for Civic Education (BPB)) significantly increase the density of the sensor network so leaks can be detected and stopped much faster,” Jentsch says. According to a study by the International Water Association, 346 million cubic meters of water is lost on the way to the consumer worldwide each day. The esti- mate for Germany is about 400 million cubic meters of water loss per year. Agriculture: plants need water to grow And those levels of loss are becoming less and less acceptable. After all, water is not only a vital resource in its own right, but also the foundation of food production. Sixty-nine percent of global water stores from groundwater and freshwater sources such as lakes and rivers are currently used for agriculture. But with the global population on the rise, the agriculture sector is expected to require as much as 50 percent more water by 2050 — even as water is increasingly in short supply due to climate change. Hydroponics, an approach that has been proposed to help with this dilemma, seems contradictory at first glance. Wouldn’t no longer grow- ing plants in a soil substrate, but entirely in containers of water instead, actually increase water use? No, says Marc Beckett, who works on development and implementation of sus- tainable water management and water use systems at Fraunhofer IGB. First, the water that supplies the plant with needed nutri- ents can be recycled, so it is enriched and reused over and over, while the water used for conventional agriculture seeps down into the soil or evaporates. That means the water doesn’t reach the plant, leading to higher water usage. “With hydroponics, we can cut water use by as much as 90 percent in these situations,” Beckett explains. Second, this form of cultivation also requires significantly less space, and because it does not depend on a specific location, it can be implemented even in urban environments, including through vertical farming. Even more important when it comes to water conservation is the fact that hydro- ponics does not necessarily require the use of potable water. Wastewater can also be used, although this does, of course, require prior purification to remove germs and other harmful substances, whether using UV light or membrane or activated charcoal filtration. The HypoWave project and its successor HypoWave+, in both of which Fraunhofer IGB is involved, are working to develop solutions for hydroponic back to page 1 15

2 | 24 Fraunhofer magazine back to page 1 17

2 | 24 Fraunhofer magazine the production of useful substances from sewage sludge. “The nitrogen that is present in high concentrations in the sewage water is especially interesting,” Mohr explains. Typically, nitrogen is pro- duced from the air for use in fertilizers, an energy-intensive process. Separating the nitrogen early on could also reduce the harmful nitrous oxide emissions that typically arise when these substances are broken down. Industry: recycling water, reclaiming raw materials The research institutes that make up the Fraunhofer Water Systems Alliance (Sys- Wasser) are also looking for innovative ways to process industrial and municipal wastewater streams so the water can be recycled in the manufacturing or agriculture sectors. This approach offers huge potential in terms of sustainable water management, as Germany’s man- ufacturing sector uses 4.5 billion cubic meters of water annually. At the same time that water conservation efforts are under way, there is also a growing aware- ness in industry that process water often contains chemicals or residual substances that could be reused in industrial appli- cations. Wastewater from metalworking businesses can even be used as a source of costly raw materials such as silver and copper, which can be extracted and then recycled. This aspect makes reclamation an exciting prospect for both environmen- tal and economic reasons. What is in the water? To find out, the Fraunhofer Institute for Photonic Microsystems IPMS has developed an integration technology that can be used in the future to measure water parameters such as pH levels and nitrate, phosphate, and potassium concentrations continu- ously in parallel and in real time, all with just one sensor chip. Multiple ion-sensi- tive field-effect transistors (ISFETs) are built into the chip to determine the con- centration of numerous ions in the water. Dr. Olaf R. Hild, head of the Chemical Sensors business unit at Fraunhofer IPMS, believes in the new technology: “This Fans of fresh fish: Dr. Henrike Seibel and Michael Schlachter from the Fraunhofer research unit IMTE focus on the circular economy. explains. This not only lowers emissions, making it easier to clean the water, but also enhances product diversity. “Aquaculture often gets a bad rap with consumers, but that’s unfair,” Seibel says. After all, the days when fish farming used huge amounts of antibiotics to prevent disease in fish stocks are over. “Consumers across the entire EU can assume that anti- biotics are rarely if ever used in aquaculture these days.” This is because advances in aquaculture long ago yielded better options, such as preventive vaccination or, in cir- cular systems, full control over water quality and the use of UV light and other methods of killing germs. Aquacultures, Seibel says, “are typically much better controlled than the water in the ocean.” — Aquaculture@Fraunhofer pooling expertise Find out more: https://www.aquakultur. fraunhofer.de/en.html back to page 1 19

2 | 24 Fraunhofer magazine “Our goal is, by the time the project ends, to have built a pilot plant that demonstrates that this method also makes economic sense on a large scale.” Dr. Cleis Santos, Fraunhofer IFAM Bright ideas: At Fraunhofer IFAM, Dr. Cleis Santos researches ways to use electrochemical processes to recover critical materials from wastewater. back to page 1 21

2 | 24 Fraunhofer magazine Dr.-Ing. Ursula Schliessmann, Deputy Director of the Fraunhofer Institute for Interfacial Engineering and Bioengineering IGB and Head of Central Office of the Fraunhofer Water Systems Alliance (SysWasser) “Switch to more drought-resistant plants.” 1 What water resource should play a larger role in tackling the threat of global water shortage? There are — and this is something we’re working on at Fraunhofer IGB, too — decentralized solutions such as capturing water from ambient moisture. But on the whole, I do think it’s necessary to ramp up our recycling of water. Within the SysWasser alliance, we’re working on concep- tual and technological tools to process water on a targeted basis and build monitoring and control systems. This is putting the structures in place so processed municipal wastewater can be used safely for applications like agricul- tural irrigation going forward. 2 How can the digital transformation help to optimize water management? Sensors, models, digital twins, and AI offer incredible application potential in terms of resource management, from monitoring water quantities and quality to optimiz- ing technical systems and facilities for water processing. At Fraunhofer IGB, we are establishing efficient data infrastructures that link process, system, and sensor data together in communication terms so we can control the entire system as well. This lets us identify solutions for competing objectives for a hydroponic greenhouse without any soil. That means things like removing nutrients as part of the wastewater purification cycle while at the same time ensuring that the plants receive an adequate supply of nutrients. 3 Can you give us a tip for daily life on how pri- vate individuals can significantly reduce their water use? The biggest impact can be achieved in the places where households use the most water: the bathroom and the kitchen. People can use low-flush toilets and turn off the water whenever they aren’t actively using it, such as when brushing their teeth, rinsing vegetables, or washing dishes. Never run a less than full load of laundry. And if you collect rainwater and it still ends up not being enough to water your plants in the summer, think about switching to more drought-resistant plants in the long term. Water guardians: Fraunhofer researchers (photo: Michael Schlachter, Fraunhofer IMTE) are working on ways to use water more effectively as a resource. “Bathing and showering are the biggest areas where people can reduce their water use.” Dr. Burkhardt Faßauer, Fraunhofer IKTS back to page 1 23

2 | 24 Fraunhofer magazine I t is colorless and dissolves eas- ily in water. But it is also toxic, a respiratory irritant with an incredibly biting smell. It reeks of urine, to be specific. That is because inside the body, ammonia — a com- pound of nitrogen and hydrogen — plays an important role as a byproduct in the formation and breakdown of amino acids, and once its job is done, it is excreted as urea. What does the pungent gas have to do with the climate crisis? What role might it play in a sustainable supply of energy? Seven Fraunhofer institutes, led by the Fraunhofer Institute for Environmental, Safety, and Energy Technology UMSICHT, are studying that very question. As part of the AMMONVEKTOR project, one of Fraunhofer’s flagship projects for 2024, they are scrutinizing the potential value chain for ammonia. Other projects are also under way in this field. AMMONPAK- TOR, at the Fraunhofer Institute for Micro- engineering and Microsystems IMM, is developing reactors, and PICASO, at the Fraunhofer Institute for Solar Energy Systems ISE, is analyzing production sites. For a long time, ammonia took a back- seat to hydrogen. “But ammonia is also a really exciting substance,” says Dr. Gunther Kolb, head of the Energy section and the deputy institute director at Fraunhofer IMM. “Right now, the gas is mainly used to produce fertilizers or as a coolant or refrigerant. But there is a lot more it could possibly be used for.” Unlike other fuels, ammonia does not generate any carbon emissions when it is burned, only water and nitrogen, which means it has potential as an emission-free option for Ammonia: bright prospects Free ammonia is a rarity in nature — only rotting plants and active volcanoes emit it as a gas. The biggest emitters are cattle, pigs, and horses. However, scientists dis- covered how to synthesize the gas with the chemical formula NH₃ over 120 years ago. A method known as the Haber–Bosch pro- cess is used to liquefy air and break it down into oxygen, nitrogen, CO₂ and water. As the next step, hydrogen derived from processes such as electrolysis of water and nitrogen can be used to produce ammonia using an iron-based catalyst at temperatures between 400 and 450°C and pressures of 120 to 220 bar. Worldwide ammonia production currently stands at about 180 million metric tons per year. back to page 1 25 o t o h p k c o t s i / c i s a p S n a v I : o t o h P

2 | 24 Fraunhofer magazine A breath of fresh air An industrial poultry house smells bad, but that’s not all. It’s also a hotbed of pathogens. To treat infections, the birds have to take antibiotics — and that poses a risk to animal and human health alike. Fraunhofer researchers are developing a different approach that involves no drugs at all. By Yvonne Weiss S ilence can be deadly. Each year, some 9,600 people in Germany die of what has been called a “silent pandemic”: bacterial infections that have become resistant to antibiotics. According to one 2022 study, antibiotic-resistant pathogens are implicated in another 45,700 deaths. And that figure is rising. The search for the root causes of this pandemic leads researchers straight to chicken coops, especially industrial ones. With thousands of birds literally cooped up together, the air is teeming with germs. Microorganisms in excrement become airborne, for example. More than 600 met- ric tons of antibiotics were used to fight infections in 2021, making these settings a breeding ground for the emergence and spread of resistant strains. Thuringia, seeking to answer various questions. What VOCs are there in the air? What about microorganisms? How much dust and other particulates are there? Once the results are on hand, the team plans to develop a demonstrator and then present it by the time the project ends, in mid-2026. Attached to the top windows in the house, the demonstrator will serve two functions at once. It will clean the exhaust before it leaves the house, removing odors, and also filter the air intake before it enters the inside. That is a crucial advantage, especially now, with bird flu on the rise: “If just one sick bird from outside flies in the window, the virus can get inside and infect the whole flock,” Westerhoff says. “Our technology has the potential to curb pandemics.” A new Fraunhofer technology keeps chickens healthy. A new, antibiotic-free approach is being studied by Thomas Westerhoff, a scientist at the Advanced Systems Technology branch AST of the Fraunhofer Institute for Optronics, System Technologies and Image Exploitation IOSB. In tandem with partners from the research sector and industry, Westerhoff is literally aiming to bring a breath of fresh air to poultry houses in Germany with UV light: “We’re developing a unit that cleans the air intake and exhaust at poultry houses. It’s based on UV LED technology.” UV light is known to damage bacterial and viral DNA, deactivating it. What is new is the LED technology Westerhoff plans to use in his machine. Not only does it have lower environmental impact than conven- tional mercury vapor lamps, it also cleans the air more efficiently. The scientist’s idea combines two mechanisms of action: LED lamps inside the air purifier are tasked with disinfect- ing the air directly while also beaming UV light at a surface holding a photocat- alyst. When the light hits that surface, the catalyst initiates a chemical reac- tion that produces molecules known as hydroxyl radicals. The radicals neutralize unpleasant odors caused by volatile organic compounds (VOCs). They also disinfect the air addi- tionally, killing both bacteria and viruses. This lowers the likelihood of infections, which means less antibiotic use, lower antibiotic levels in meat, and less resis- tance among pathogens. Esterhoff and his team are currently studying a poultry facility in the state of back to page 1 27 k c o t S e b o d A / a y a k s d e s n o S : o t o h P

2 | 24 Fraunhofer magazine P rosperity without growth.” “Right- sizing.” “Green growth only.” Any- one who has been following public debate in Germany in recent years about the right economic strategies might easily conclude that economic growth has outlived its usefulness as a necessary and desirable objective. That it is incompatible with efforts, both important and morally correct, toward greater climate action and resource conservation. That responsibility and growth are incompatible and even mutually exclusive. But is that actually the case? Has economic growth shaped our understanding of a modern economy for too long? Was it, and is it, the wrong benchmark for an economy’s perfor- mance and important decisions by investors, companies, and policymakers? The answer is no. A growing economy remains an expression of economic success, increasing prosperity, social progress, and a society’s future viability, all of which is positive. For an economic area like Europe in general and an export-oriented economic powerhouse like Germany in particular, qualitative and quantitative growth remains a must. What’s more, sustainable economic growth has arguably never before been so crucial in enabling the step-by-step transition across our industries and entire economies toward a way of doing business that is compatible with our climate goals while conserving resources. For one thing, a growing company offers career opportunities and development pros- pects, making it more attractive to existing employees and new talent. And that is an increasingly important factor in light of the shortage of skilled workers and workers in general. Growth is also fundamental to capital-in- tensive investment of all kinds, whether in new business models or exploration of new markets. Or even, most especially, in research and development for future technologies that will make more-sustainable business possible in the first place. And I’d like to point out that sustainable growth doesn’t come in just one l k c ä H r e n a R i : o t o h P “Growth is fundamental to capital-intensive investment — most especially in research and development of future technologies.” Oliver Zipse became the CEO of BMW AG, which has more than 150,000 employees worldwide, in August 2019. His contract was just recently renewed for two years, until August 2026. “bucks the trend,” as the Frankfurter Allgemeine Zei- tung recently wrote about him. Zipse is a staunch advo- cate of openness to technol- ogy. He opened his speech to the general meeting in May by saying, “Here at BMW, we are different.” BMW is continuing to build gasoline engines and forging ahead with research on hydrogen drives. joined BMW AG as a trainee in 1991 and has stayed with the group his entire career, in roles including Senior Vice President Technical Planning and, in 2012, Senior Vice President Corporate Planning and Prod- uct Strategy. studied computer science and mathematics at the University of Utah and went on to earn a Diplom degree in general mechanical engineering at the Technical University of Darm- stadt. He has been an honor- ary professor at the Technical University of Munich since 2022. was born in Heidelberg, Ger- many, on February 7, 1964. Zipse is married and has two grown sons. back to page 1 color. It spans many different shades. Wind turbines, heat pumps, electric cars — all the products we think of as green are developed by technicians and engineers and then made in factories, by blue-collar workers. That’s why sustainable growth, in all its many colors and aspects, needs to remain a key element of our economic and industrial policy. This belief, and the unmistakable public commitment to growth that goes with it, is sorely lacking in the political debate in this country. We’re not talking about quarterly GDP figures here. It’s about the fundamental ques- tion of what role growth should play in Ger- many and the wider ramifications of this kind of decision. No investor will decide to put money into projects in a place that doesn’t have any stated growth ambitions. Instead, invest- ments are made in more-promising economic areas, and in the worst case, there is a threat of spiraling deindustrialization. A commitment to sustainable growth must be accompanied, including at the European level, by a mental paradigm shift. Instead of hastily slapping bans on things and mapping out exit strategies, we should put the same energy into entry strategies that set the stage for growth. Simply prohibiting and ending something doesn’t automatically mean some- thing new and better will take its place. In addition, growth no longer necessarily means increasing environmental impact, whether that is measured in carbon emissions or resource consumption. Where, if not in Germany as a high-tech hub, do we have the skill and talent to, for example, develop and apply innovative production methods that lead to greater efficiency in manufacturing pro- cesses? Instead of constantly coming up with new bans, there should be positive incentives for a responsible path to growth with elements of a circular economy and carbon reduction. A path that reflects Germany’s strengths in research, science, and industry and promotes them as factors critical to success. Charting the right course for this is a fundamental task for our policymakers, and an urgent one. 29

2 | 24 Fraunhofer magazine I t starts with bleeding gums. Left untreated, gum disease can progress to tooth loss and is even suspected of contributing to other serious diseases. Persistent bacterial infections of the gums are implicated in diabetes, rheu- matism, Alzheimer’s disease, and chronic bowel disease. This means serious cases of periodontitis are typically treated with antibiotics. But there are two issues with that. First, these kinds of medications kill more than just harmful bacteria. They also kill the good bacteria present in the mouth flora. Second, since gum disease is so common, use of antibiotics is widespread, and that is contributing to antibiotic resistance. The Global Research on Antimicrobial Resistance (GRAM) Report points out the consequences of antibiotic overuse: In 2019, 1.27 million people worldwide died of infections caused by multidrug-resistant germs. Fraunhofer spin-off PerioTrap Pharma- ceuticals GmbH is working with partners to minimize these kinds of risks. Inhibiting the effects of bacteria instead of killing them In the Paropaste project, the research- ers are working together to develop a completely new approach to not only treating gum disease, but preventing it altogether: Instead of killing pathogenic bacteria in the mouth, the idea is to use a specific active ingredient to merely “defang” them. It does this by inhibiting an enzyme found almost exclusively in these bacteria. Without the enzymatic effect, the pathogens can no longer cause any harm, but they also do not die off. Dr. Mirko Buchholz, CSO and co-founder of PerioTrap Pharmaceuticals GmbH, explains the principle: “Traditional anti- biotics impair the fundamental growth of all germs, good and bad. Our goal is to use something called a patho-blocker to inhibit only the pathogenic effect of harmful bacteria. This preserves the natural microbiome in the oral cavity, and it doesn’t create any niches for other pathogens to colonize.” The innovative treatment method was first devised in several places, including the Department of Drug Design and Target Validation of the Fraunhofer Institute for Cell Therapy and Immunology IZI. Perio- Trap Pharmaceuticals GmbH was spun off in the city of Halle in 2019. As part of the project, which is receiving funding from the German Federal Ministry of Education and Research (BMBF), the partners are now working to further optimize the substance using more complex microbiological sys- tems. To that end, they are developing new bioanalytical methods, testing local bio- availability, and studying drug delivery and toxicity. “We already have a wealth of data from in-vitro experiments,” Buchholz says. “It confirms that this chemical com- pound is highly tolerable, and that there are no health concerns up to very high concentrations.” The project team is being supported in developing the right formu- lation and in the associated scale-up processes by Skinomics GmbH, a service provider also based in Halle. One of the big challenges is the method of delivery: How can the active substance be applied directly inside the mouth in such a way that it stays where it is needed for long enough without simply being swallowed right away? To answer that question, PerioTrap turned to another Fraunhofer institute in the immediate vicinity for its expertise in materials sci- ence. Researchers at the Fraunhofer Insti- tute for Microstructure of Materials and Systems IMWS, also in Halle, study not only how different formulations can be distributed effectively, how well they stick, and how readily they release active sub- stances, but also how they interact with dental tissue and foods. The goal of all this is to prevent undesired side effects such as discoloration. Based on the active sub- stance and the formulation, the team is currently developing a dental gel intended to prevent gum inflammation. To treat advanced cases of periodonti- tis, the partners worked with Prof. Karsten Mäder from the Pharmaceutical Technol- ogy Group at Martin Luther University Halle-Wittenberg to develop another approach in an earlier project. With that method, short threads are used to deliver an approved antibiotic active ingredient directly to the inflamed pockets around the teeth. The threads are broken down, and the antibiotic is released locally over a long period. This strategy enables tar- geted, limited use of antibiotics. Since the effect is limited to the pockets themselves and no antibiotics reach the gastrointes- tinal tract, the likelihood of resistance is also very low. Prophylaxis and treatment Buchholz explains how complemen- tary the two approaches are: “The new enzyme-inhibiting active ingredient has more of a prophylactic effect, for example in that it specifically targets pathogenic bacteria in a gel that clings to the surface, thereby preventing the formation of the toxic biofilm that causes gum disease.” And what if the disease is already advanced and causing symptoms? “Then the antibiotic threads help locally, extending the therapeutic success of dental treatment without burdening the entire organism with antibiotics.” The team is currently working toward approval for both methods. Because the antibiotic threads contain a known active ingredient, they could be available in as little as two to three years. Approval pro- cesses for medicinal products involving entirely new drugs typically take seven years or longer, by contrast. This is why in addition to the ongoing project, PerioTrap is also planning to launch a toothpaste with a significantly lower concentration to maintain oral health on the market faster as a cosmetic product. That means the microbiome-preserving properties of the new approach could benefit many people not too long from now — and, in the future, prevent complex periodontitis treatments. After all, an ounce of prevention is worth a pound of cure, as the saying goes. back to page 1 31 l e r u t c i p n a p / g r e b e g g ü R s i d r o h T : i o t o h P

Detecting and defending against cyberattacks in real time is the subject of the Locked Shields exercise, which has been running annually since 2010. 2 | 24 Fraunhofer magazine r h e w s e d n u B / j U n a f e t S , t r e n n a L r e k o V l : s o t o h P Locked Shields: 3,500 IT specialists from 32 member states participated. back to page 1 33

2 | 24 Fraunhofer magazine Knowledge relay new directions: AI change ? back to page 1 35

2 | 24 Fraunhofer magazine Knowledge relay Upheaval and new directions: Prof. Hanselka, how will AI change our world? back to page 1 35

2 | 24 Fraunhofer magazine We shouldn’t let these challenges discourage us, let alone retreat from them. On the contrary, Germany — and Europe as a whole — must take swift and decisive action to transfer innovative AI technol- ogies, even beyond purely generative AI and large language models, into broad industrial application both quickly and securely. If we allow ourselves to be left behind now, we run the risk of even greater dependence and a widening innovation gap as a result of the rising dominance of AI platforms from the United States and China. Upheaval and new directions: AI has already changed our world and is hav- ing an impact at every level of national economies and the business sector. The spread of AI systems cannot be halted at this point without causing a huge setback in terms of prosperity, competitiveness, and ability to innovate. What we need to do now is forge boldly ahead and take the future into our own hands. It’s up to us, and it’s our responsibility, to decide how our AI systems will be designed and what purposes we use them for. Right now, the growing and increas- ingly innovative use of AI technologies and systems marks the dawn of a new era, one in which AI will also act as a catalyst and a cross-cutting technology for change and transformation: 1. AI makes us faster Machine learning and AI can be used to analyze large volumes of data fast and identify complex patterns accurately. This means systems like these can also learn and improve on a continuous basis. New insights and connections can be unlocked faster, which in turn increases the pace of innovation and dramatically accelerates advances in science and technology. 2. AI boosts economic output AI technologies can be used to auto- mate routine tasks, but that is not all. With sufficient processing power, they can also handle complex tasks and pro- cesses, 24/7. That makes it possible to ramp up production volumes even as the error rate goes down. AI systems and robots would thus make a substan- tial contribution to boosting overall economic output — all without need- ing to take breaks or be paid a wage. Especially now, amid the shortage of skilled workers, that holds out great potential for reserving human labor for higher-order tasks and management of AI systems. 3. AI creates new business models and Holger Hanselka has been the president of the Fraunhofer-Gesellschaft since August 15, 2023. done on that score, for example for the use of training data, especially compa- ny-specific training data, in secure data spaces, solutions that address the large amounts of resources currently being used up to train and host models, and fine-tuning for reliable applications. industries Not only are AI technologies evolv- ing at a rapid pace, opening up new opportunities for automation, analysis, and decision making, but demand for AI-supported products and services is also rising steadily. Entrepreneurial thinking and actions and effective knowledge transfer between stake- holders in the research sector and private enterprise can, will, and must give rise to whole new (disruptive) business models and industries. But there is still quite a bit of work to be The growing capabilities of our AI systems have also already produced acute issues, as we are seeing right now in the form of fakes, abuse, poor data quality, and high resource usage (energy, water, micro- electronics, specialists, and so on). Swift action is needed here so we can lay the technological and social groundwork for a future in which AI is used reliably and responsibly, in a way that can be trusted and aligns with our values. What is not very helpful is vague fears and nebulous debate about hypothetical worst-case scenarios in a distant future. In the next issue: What can research do for our safety in these troubled times? back to page 1 37 r e i e m r e b O n a f e t S / r e f o h n u a r F : : o s t o o t h o P F

Prof. Martin Steinebach doesn’t actually need to build a monument to himself like the one here, at Mount Rushmore, since his expertise in media forensics is sought after in government and industry. But he does it anyway — thanks to deepfake technologies. 2 | 24 Fraunhofer magazine “Hardly anyone would have thought the methods of making deepfakes would evolve at such a breakneck pace.” Prof. Martin Steinebach, Fraunhofer SIT O laf Scholz, the German chancellor, gives a speech in which he announces that the AfD political party has been banned. Donald Trump is shown being arrested. Ukrainian president Volodymyr Zelenskyy capitulates on his country’s behalf. Plenty of people would be happy to see these news items. But these videos and images aren’t of real events; they’re deepfakes. Just like the one of Tom Cruise accusing the International Olympic Committee (IOC) of corruption, shortly before the Paris Olympics, and the various steamy videos purporting to show superstar Taylor Swift that are all over the internet. Image manipulation and disinformation have always existed, especially in the run-up to elections. But creating deceptively realistic fake content has never before been as easy as it is today: With the right prompts and a little adjustment, photos of situations that never occurred can be created en masse. Just a single photo and a short audio clip can be used to put words in people’s mouths that they never said. A few seconds of authentic voice recording is enough to generate fake clips of an allegedly conspiratorial phone call. The days when people could trust their own senses are long gone. “Hardly anyone would have thought the methods of making deepfakes would evolve at such a breakneck pace,” says Prof. Martin Steinebach. “Two years ago, you still needed good actors to make deepfake videos seem even remotely realistic, but today, some deepfakes almost look better than the original.” Steinebach, a multimedia forensics expert, has been working on technical recognition methods at the Fraunhofer Institute for Secure Information Technology SIT in Darmstadt for years now. He studies how different methods of creating the fakes work, what traces they leave, and how those can be detected automatically. What is new is not only the quality, but also the quantity, of disinformation campaigns: Spamouflage, a campaign operated by a Chinese network, spans T I S r e f o h n u a r F , i a . t r a a e s h t i w d e t i d e , o t o h p k c o t S i / o t o h p k c o t s e k c a b l : s o t o h P back to page 1 39

2 | 24 Fraunhofer magazine Keeping a level head even amid the rising tide of disinformation: Fraunhofer scientist Steinebach — here, as the Buddha in Thailand — uses practiced judgment and analytical tools to identify deepfakes. i a . t r a a e s h t i w d e t i d e , o t o h p k c o t S i / i c i p a Y l i l a H m h a r b i I : o t o h P back to page 1 41

2 | 24 Fraunhofer magazine “Just 20 seconds of audio material is enough these days to filter out typical voice characteristics and use them to generate whole new sentences.” Nicolas Müller, Fraunhofer AISEC flagged as fake. The terrorists then used AI to generate a new picture in which they swapped the children for dead dogs and said that was the real photo. This was intended to discredit all the other photos that were not flagged as fake by association, suggesting that the Israelis were deceiving the public. The British royal family also had its own experience with this kind of “false positive” this past spring. All it took to touch off a firestorm of scandal was for an online detector to find irregularities in a family photo of the royals. A whole host of experts chimed in that there was nothing suspicious about it, just standard photo editing like the kind many amateur photogra- phers do, but their voices were almost drowned out in the breathless reporting. With detection of fakes still that error-prone, a different method can help to at least recognize the originals: “The only strategy people can be relatively sure of today is a positive signature: Newer digital cameras leave a cryptographic signature in their pic- tures that is difficult to falsify. There are also cell phone apps that do this,” Steinebach says. “Big tech companies are also working on new security strategies in which, like with blockchain, all of the steps in processing an image are signed and stored, for example.” The royals and others should be pleased to hear that. Deepfake audio: Don’t believe your ears “Voice cloning” techniques are increasingly popular with criminals. Attackers used voice cloning to influ- ence the Slovakian parliamentary elections in 2023. Two days before the election, social media was abuzz with an audio clip purporting to be of a prominent journalist and the head of the Progressive Slovakia party, talking about how to rig the elections. The fake discussion never happened, but the clip reached thousands of users. Democratic voters in the U.S. got a surprise at the start of this year, too: a personal call from Joe Biden asking them not to vote in the prima- ries. The U.S. president’s voice was AI-generated, and the calls were made automatically. “Just 20 seconds of audio material is enough these days to filter out typical voice characteristics and use them to generate whole new sentences,” says security expert Nicolas Müller from the Fraunhofer Institute for Applied and Integrated Security AISEC in Garch- ing, describing a machine learning technique known as few-shot learning. A short clip of a public speech is sufficient to manipulate discussions or presentations. A year ago, many programs still could not manage to consistently falsify a minimum of 16,000 data points per second, but with AI, that’s not an issue now. Plus, it works in near real time. Still, Müller says there are clues to be found in these cases, too, if you really listen closely: “An AI-generated voice is monotonous in some cases, with unnatural intonation, subtle delays, and little emotion.” The security experts at Fraunhofer AISEC also use AI for counterattacks: They train and develop solutions to automatically unmask audio deepfakes. To do this, they first generate artificial audio and video data and then use the information to develop algorithms that recognize the fakes from the tiniest discrepancies, barely noticeable to humans. The Fraunhofer AISEC researchers provide their developments to the general public online at deepfake-total.com. Links or files can be uploaded there to test whether the content is fake. “These kinds of tools generally have an easier time recognizing recordings from known generators than content from entirely new sources,” Müller says. The increasing quality of audio fakes is also increas- ing the direct risk of fraud. Müller advises anyone who receives a suspicious call from a relative or friend asking them to transfer funds quickly or disclose confidential information to hang up and call back, if at all possible using a different channel. He and his team are also researching methods to make systems for facial recognition or voice authentication, such as voice ID systems, more robust and resilient to manip- ulation and attacks. Aside from the risks, the researcher also believes it is important to point out the possibil- ities unlocked by speech generators. “For example, they can help people with speech impediments to be understood better, or even at all, by voice assistants or other people.” Right now, for example, Google is researching AI that can translate atypical, hard-to-un- derstand speech into fluent speech. Speed versus careful attention: the social media dilemma Where fake content is concerned, it is also worth looking at how it spreads. Social media platforms are obligated to flag suspicious content, but they have a hard time keeping up. After all, it’s a lengthy process. First, they need to recognize whether the content is problematic. This is either done by internal research teams, or the company relies on user reports, which is anything but reliable and effective. That’s because nothing is black and white: “Telling whether content is entertainment or actual news, whether it should be taken seriously or is exaggerated satire, is hard for both people and machines,” Steinebach says. “And r e h t ü R r e v i l O , i a . t r a a e s h t i w d e t i d e , o t o h p k c o t S i / 3 o n o t r e c n o c n i l o i v : s o t o h P back to page 1 43

2 | 24 Fraunhofer magazine the texts confirm or refute the original statement. This means they must also be able to reliably recognize synonyms and alternative phrasings. One issue is that there is often a lack of public data records that can be used to train the AI. That means finding suitable data will still be a lot of work for the developers. AI tools are not a substitute for critical thinking Whether they are applied to images, audio, or text, technical detection methods can ultimately only pro- vide clues to where a closer look is needed. Ultimately, it is still up to individuals to decide for themselves what is plausible and what is true or false. “We do have some concerns about the widespread belief in some corners of government and across society that technology alone will be enough to counteract dis- information campaigns or AI will be able to decide for us what is true or untrue,” Steinebach cautions. “That’s too easy an answer. AI is no better at judgment calls than a human.” That means AI tools will also be unable to provide simple answers in situations where most people already have a hard time making sound decisions. Unfortu- nately, that is exactly the kind of subject targeted by disinformation campaigns: Manipulators have been most active during the coronavirus pandemic, the war in Ukraine, and the current conflict in the Middle East. “The most dangerous fakes are always the ones containing a kernel of truth. But those are also the hardest to detect — by humans and AI alike,” Steine- bach says. Still, he has a tip for public figures and politicians in particular, who are often the victims of campaigns like these. He recommends that they build research infrastructure. “It could be databases or sections of a website where all the official image and video material is stored. Forensic technicians could then compare possible fakes against that material, making them easier to detect.” It is understandable that people are looking for easy answers at a time of complex information situations and uncertainty, but AI will not substitute for critical thinking and making our own decisions. Instead, we all face a difficult balancing act between guarding against disinformation on the one hand and protecting freedom of expression on the other. And the only way we will strike that balance successfully is through broad discourse across society, finely honed media literacy skills, and a vigilant and critical public. — Click here to listen to the Deepfakes podcast. In his guise as a statue of Christ over Lisbon, Steinebach preaches education instead of blind faith in technology: AI will not decide for us what is true or untrue. i a . t r a a e s h t i w d e t i d e , o t o h p k c o t S i / a v o k u K a l i r a D : o t o h P 45 back to page 1

2 | 24 Fraunhofer magazine Ms. Faeser, it’s an election year in Germany. Are we adequately prepared for cyberattacks? Cyberattacks can never be entirely prevented, but our agencies are ready and sparing no effort to protect our elections against these kinds of attacks. The Federal Returning Officer, who oversees elections at the federal level, and all the other electoral bodies at the state and district levels are taking action to keep our elections secure. The German Federal Office for Information Security (BSI) is supporting them in these efforts and providing advice and information. But the very best protection is still our paper ballots. When the national report on the cybercrime situation was unveiled, you pointed out that there has been an increase in politically motivated hacking activity since the start of Russia’s war of aggression against Ukraine. That’s the quantity aspect. What signs are you seeing of a difference in quality? Let’s take DDoS attacks as an example. The goal of these attacks is to deliberately overwhelm Internet services by flooding them with traffic. These kinds of attacks are gaining in intensity, and it takes less and less time for them to reach a critical stage. Plus, the perpetrators are getting more and more professional. Our security agencies see this as another point where things have been exacerbated since the start of Rus- sia’s war of aggression against Ukraine. Pro-Russian “hacktivists” deliberately target government agency websites, for example. In most cases, they don’t do much damage. But we assume there is a clear strategy behind all this: to sow confusion in our communities and damage trust in democratic institutions and in the state’s ability to protect the populace. Putin’s hackers attacked the German federal parliament (Bundestag) back in 2015. Almost ten years have gone by. What have security agencies done in that time to improve protection? One very important point is that we’ve strengthened the security agencies themselves, in terms of both adding staff and expanding their expertise. We’ve made great progress in detecting and analyzing cyberattacks, for example. Another crucial point is that our agencies are working together even more closely, including internationally. And we’re putting more effort into raising awareness in the general public and among potential victims than before, which is something the German Federal Office for the Protection of the Constitution and the BSI, our cybersecurity authority, are spearheading. But that’s not enough on its own. I’m working to ensure that we take other important steps. The BSI needs to be empowered to act faster and with greater ease. And not just when government agencies come under “We definitely want to promote the use of AI and cultivation of AI in Germany.” Nancy Faeser attack, either, but also when the targets are places like universities or medium-sized businesses. It’s all been much too complicated in the past. To fix that, we plan to further improve collaboration between the German federal and state governments and expand the BSI into a central agency, like the Federal Criminal Police Office, the BKA. Chancellor Olaf Scholz has repeatedly affirmed that Germany cannot become a party to an armed conflict. But didn’t Germany become a target for the Russian war effort long ago? In my role as federal interior minister, I am watching with concern, just like the chancellor, the impact that Russian aggression against Ukraine is having on the security situation in our country as well. Cyberspace plays an important role in this, of course. Yes, Germany has been targeted by Russian meddling attempts to exert influence and spread uncertainty. But the critical point there is that we take the situation seriously and are hardening our defenses against these threats. And let me reiterate loud and clear: We will never be intimidated by the Russian regime. We will continue to make every effort to protect our democracy — and we will con- tinue to provide massive support to Ukraine. There has been debate in Germany about military helmets, about tanks and rockets. But should we also get used to picturing war a differ- ent way? We can see what war means from the terrible Rus- sian attacks on the civilian population of Ukraine. So we should be careful with terms like that. But it’s clear that we do need to grapple with changing realities. For example, we need to strengthen not just military defense, but civil defense as well, for exam- ple through a strong Federal Agency for Technical Relief that springs into action in a crisis or disaster. And, of course, we need effective preparations to defend against hybrid threats like cyberattacks, disinformation, and espionage. We’ve massively strengthened our security agencies in these areas. back to page 1 47 f i a l / s u a h t l o H s n e J : o t o h P

“Thanks to research, we have quantum-secure encryption mechanisms that are ready to deploy today. The challenge now is to get them into use.” Nancy Faeser bution, not just in enhancing the security of AI applications, but also in developing AI applica- tions that are themselves aimed at enhancing cybersecurity. Let me give another example: We’re on the cusp of a big change in some of the fundamental elements of cybersecurity, by which I mean the methods used for encryption and authentication. Quantum computers could crack those in the not-too-distant future. That’s why we need to act fast now to start rolling out new methods that are resistant to these kinds of attacks. Researchers started working to develop these kinds of quantum-secure methods decades ago, back when quantum computers were just a theoretical concept. Thanks to their findings, we have quantum-secure encryption and authentication mechanisms that are ready to deploy today. The challenge now is to get them into use. As the Federal Minister of the Interior, you deal with a lot of “isms”: Right-wing and left-wing extremism, antisemitism, Islamism, racism, sexism. Where do you think the biggest danger lies? The biggest extremist threat to our democracy is right-wing extremism. At the same time, we’re extremely vigilant about the threat of Islamist terrorism, left-wing extremism, and the hybrid external threats we’ve already talked about. We need to be on our guard in all directions. We’ve seen a sharp increase in antisemitic crime since the terrible terrorist attack by Hamas on Israel on October 7, 2023. There is also an increase in incidents of violence against politically engaged people from all parties. Just recently, the terri- ble knife attack in Mannheim by a presumed Islamist that cost a young policeman his life really shook the country. Our security agencies are working to contain all of these threats. You’re a first in two important ways: the first Federal Minister of the Interior to come from the SPD party since Otto Schily, almost 20 years ago, and the first woman ever to serve in this position. What do you see as the main areas of focus in your work? Everyone has their own way of holding an office like this. And every period has its challenges. To me, security is also a question of social justice. Our government and legal system needs to pro- tect everyone, regardless of where their families might once have come from, how much money they have, what they believe in, and who they love. In my role, I try to see the perspectives of those who are threatened by extremism or criminal activity along with others. My close contact with families of the victims of the hor- rendous racist murders in Hanau was really for- mative for me, as was my work on the campaign of terror perpetrated by the National Socialist Underground, the NSU. Those experiences had such an impact, in fact, that they still inform my actions today. back to page 1 2 | 24 Fraunhofer magazine The first woman in office Faeser takes the oath of office as Interior Minister before Bundestag President Bärbel Bas on December 7, 2021. She is the first woman ever to hold this office, and the first Interior Minister from the SPD party in nearly 20 years. The man by her side The Federal Minister of the Interior with husband Eyke Grüning, local SPD politician and attorney. Faeser also studied law. One of her key practice areas at a major firm was real estate law. Politics even at the stadium FIFA has banned captain’s armbands on the pitch, so the minister wears one in the stands at Germany’s first game at the Qatar World Cup. They end up losing the game to Japan, but Faes- er and German Football Association (DFB) president Bernd Neuen- dorf have fun anyway. 49 a p d / r e l l e W m o T , s e g a m i p d d , a p d / s s e r p o t o F - r e l s i e G / n r e K c i r e d e r F , h c i l ü J r e t e P , s e g a m i o g a m i / r e s l e f n e t r a H r e t e P , s e g a m i p d d / r e s e O n i t r a M , f i a l / h c i l ü J r e t e P : s o t o h P

2 | 24 Fraunhofer magazine T he patient complains of fatigue, lack of appetite, abdominal pain. It could be a gastrointestinal bug or some form of gastritis — or it could also be Wilson’s disease. This genetic, life-threatening metabolic disorder is one of the approximately 6,000 “rare diseases” listed worldwide to date. What all of them have in common is that the symptoms are generally nonspecific. As a result, it takes six years on average for patients to receive the correct diagnosis — which Dr. Andreas Jedlitschka and Patricia Kelbert from the Fraunhofer Institute for Experimental Software Engineering IESE think is too long. In cooperation with the university medical centers in Frankfurt am Main and Dresden, they are working on an AI-based portal called SATURN, which aims to pro- vide future support to doctors during the diagnostic process. In the EU, a disease or condition is considered “rare” if it affects fewer than one in 2,000 people. This means there is not much data on these issues. Jedlitschka explains: “With this in mind, we combine different AI methods to arrive at the best result, meaning the most likely diagnosis.” A technique known as “case-based rea- soning” compares the current case against clinical data from other cases and makes inferences based on similarities. The “rule- based approach” extracts principles from medical guidelines and interviews with experts and then uses those to make a diagnosis. The research team’s objective is ultimately to harness various machine learning methods to identify characteris- tic features of diseases and disease patterns from clinical case data. Tools for diagnosing rare diseases and conditions are already available on the market. But often, they are inaccurate because they are typically based on a small pool of data and a single AI method. “There is seldom transparency around how certain the diagnosis is, or even how it is made,” says Jedlitschka, who heads the Data Science department at Fraun- hofer IESE. And that, he says, causes patients unnecessary anxiety. Many do not know that the answers they receive are only probability values. “In some cases, the likelihood might be as low as 30 percent or less,” Jedlitschka cautions. The AI has often been trained exclusively with data on rare diseases, so it ultimately diagnoses one of those conditions in every single case — even if there is a 95 percent chance that the patient actually has the In the EU, a disease or condition is considered “rare” if it affects no more than one in 2,000 people. This means there is not much data on these issues. flu. Most users of diagnosis apps are not aware of this. With this situation in mind, SATURN is to be provided exclusively to physicians in order to help them inves- tigate suspected cases. This is because doctors should be able to interpret the results correctly. There are also plans to connect the tool to the SE Atlas, an online information platform operated by Goethe University Frankfurt that lists medical centers for rare diseases and conditions, specialists, and numerous tips. An initial test version of SATURN already exists. It is based on medical lit- erature as well as patient data for about 20 different diseases, which the cooperation partners provide in a structured, ano- nymized form. “Right now, we’re inter- viewing medical specialists to incorporate their specific knowledge and experiences into our AI models as well,” explains Kel- bert, who is a bioinformatics expert. The goal, she says, is to give primary care providers — typically the first point of contact for patients — a concrete tool to help them make decisions. What questions should they ask to corroborate or rule out a suspected diagnosis? What aspects require special attention? “If we screen more effectively beforehand, we can also significantly relieve the burden on spe- cialist practices, which are typically where patients turn for further guidance,” Kelbert says. To make the AI’s decisions as transparent and understandable as possible, the portal displays the percentage certainty behind the diagnosis and the data and sources used to arrive at the final outcome. “So, for example, the system might report that this information is an 80 percent match for Wilson’s disease. The symptoms are listed in the treatment guidelines for the most part, we have a number of compara- ble cases, and the expert interviews also substantiate this suspicion. But symptoms X and Y are still lacking.” More training data will be needed in order to further improve the AI models. Especially in the area of rare diseases and conditions, where data is sparse, it would be important to gather and analyze data worldwide to improve the quality of care. The European Commission took the first step in this direction five years ago. The European Platform on Rare Disease Reg- istration was established to enable the exchange of data on diagnosis, treatment methods, and care for patients with rare diseases, which has thus far been spread around hundreds of different registers — all of which are subject to the EU’s stringent data protection rules. “Unfortunately, it’s really complicated for research projects to get their hands on this data,” Kelbert says. The groups of patients with whom the scientists are in touch would like to share their data so they can spare others the lengthy suffering they have experienced. “I hope we can find a way to simplify medical research using health data here in Germany,” Jedlitschka says, adding: “The potential is huge.” back to page 1 51 i l e r u t c i p n a p / r e n r o D + z t i b u L : o t o h P

2 | 24 Fraunhofer magazine It’s what’s inside that counts: Electric cars are to become even more sustainable, thanks to resource-conserving production methods. — Fraunhofer Transport Alliance For more info on the future of the automotive sector, visit www.verkehr.fraunhofer.de/ en.html targets set out in the German Federal Climate Change Act (Klimaschutzgesetz, KSG), which the Bundesrat approved on a final basis in May. “Based on what we currently know, it would make no sense to stubbornly cling to the combustion pro- cess as a drive option. Electric motors are much more efficient, plus they are climate neutral.” Prof. Thilo Bein, another mem- ber of the Fraunhofer Transport Alliance and the head of knowledge management at the Fraunhofer Institute for Structural Durability and System Reliability LBF, concurs: “Cars will definitely be powered by electric batteries in the future. But for smaller, medium, and large commercial vehicles, we’ll see a diversification in pow- ertrains. Hydrogen, e-fuels, and fuel cells could also be used in this segment, at least for long-haul transportation.” The charging infrastructure has some catching up to do. According to figures from the German Federal Network Agency, there were 120,500 EV charging points in Germany in November 2023. That number is rising, but right next door in the Netherlands, charging points are springing up everywhere. There are 144,450 charging stations, which works out to 111.8 charging points for every 100 kilometers of road — more than twice as many as in Germany. The country needs to keep up on two fronts: charging infrastructure and EV production. “The competitiveness of technological solu- tions really counts — success will only come to those who can manufacture them cost-efficiently in global competition,” Horch notes. Scientists at the Fraunhofer Research Fab Battery Cells FFB in Münster have been working on this for three years now. The facilit y, which encompasses some 6,800 square meters of research space, aims to advance the production processes for battery cells made in Germany. The pro- tected environment provided by the FFB PreFab gives partners from a wide range of industries the opportunity to work with Fraunhofer researchers to run through their development and commercialization processes for existing and future cell for- mats at an accelerated pace. “Through our work, we can help lower the manufactur- ing costs of battery cells,” explains Dr. Thomas Paulsen, head of the Strategic Busi- ness Development department at Fraun- hofer FFB. “The cell is one of the most important parts of a battery pack. So if, for example, we can reduce the waste gen- erated during ramp-up of a production facility, that drives costs down as well,” he points out. “This means our work is help- ing to make batteries for EVs cheaper and achieve technological sovereignty in Europe as well, since so far, about 80 per- cent of the battery cells in European cars come from Asia.” There are plans to build another 20,000 square meters of produc- tion and research space soon to enable industrial production research in the giga- watt range, marking an important step toward an electrified future in the auto- motive sector. back to page 1 53 i W M B / d e m h c S r e t n e u G : o t o h P

2 | 24 Fraunhofer magazine E lectric bikes and cars defi- nitely work for everyday use. But long-haul electric trucks? Semis pulling two or more trailers (longer combination vehicles, or LCVs) with heavy goods from a port in the Netherlands clear across Germany to East- ern or Southeastern Europe? “We have the technology to build an electric truck with a range of 1,000 kilometers with no prob- lem. Both batteries and charging perfor- mance have improved significantly,” says Dr. Patrick Plötz, head of the Energy Sector business unit at the Fraunhofer Institute for Systems and Innovation Research ISI. “But that big a range isn’t even necessary in most cases. It would only drive costs up for no reason.” Fast-charging infrastructure for EU Member States Most of the trucks zipping back and forth down Europe’s highways are crewed by just one driver — and by law, that driver has to take at least a 45-minute break after 4.5 hours on the road. The driver uses that time to recharge, and going forward, so could the truck’s batteries. “A real-world range of 500 kilometers would be more than enough in that scenario. The sticking point is the fast-charging infrastructure,” Plötz explains. “Long-haul electric truck- ing is still in its infancy,” he admits. But the EU is hoping to spur development in this area: To lower greenhouse gas emis- sions from traffic and transportation, and especially from heavy trucks, all EU Mem- ber States are required to build alternative fuel infrastructure in the next few years. And that especially includes building pub- lic fast-charging infrastructure for trucks along major highways. EU regulations have also set minimum requirements. Plans call for about 2,800 charging stations to be built Europe-wide along the nearly 110,000 kilometers of trans-European transportation networks by 2030. The new stations are to have at least 7.5 gigawatts of charging power in total. Researchers are studying the challenges involved as part of the HoLa project, which is exploring high-performance charging for long-haul trucking. Four truck manu- facturers — Daimler, Volvo, MAN and Sca- nia — are taking part, along with charging station manufacturers and the Fraunhofer Institute for Industrial Engineering IAO. Fraunhofer ISI is in charge of overall proj- ect management for HoLa, which was launched in 2021 and is scheduled to run until the end of September 2025. The proj- ect is receiving a total of 12 million euros in funding from the German Federal Min- istry for Digital and Transport (BMDV), since after all, it serves to test this new system. Plötz, the project manager in charge, puts it this way: “We want to incor- porate electric trucks into logistics pro- cesses early on, test new fast charging capa- bilities, and build experience from real-world operation — and, of course, use our data to pave the way for this technol- ogy to be rolled out across the board.” “By 2030, we’ll need at least 1,000 megawatt charging points at 142 locations in Germany if we don’t want drivers to have to wait more than five minutes for a free charger even during rush hour.” Dr. Patrick Plötz, Fraunhofer ISI Test charging stations along Germany’s A2 The first step will be showing that the megawatt charging approach works. This feasibility demonstration is taking place on the A2 autobahn between Berlin and the Ruhr region. The project team is set- ting up charging stations at five locations, each one initially featuring two chargers that use the current standard, the Com- bined Charging System (CCS), so they are rated for about 400 kilowatts. At the same time, the project partners are also developing the Megawatt Charging Sys- tem (MCS), which will be used to upgrade four of the five charging stations and make them the first public megawatt truck chargers in Germany. Long-term plans for regular and fast-charging stations to operate alongside each other, since after all, current electric truck models are not yet equipped for rapid charging. The producers are providing the logistics companies involved in the project with at least two CCS vehicles and one megawatt charging-capable vehicle each to serve as prototypes for real-world testing. How much megawatt charging is needed? The Fraunhofer institutes are focusing on researching the field: How many of these chargers will be needed, and when? And what might a charging network be like — not just for Germany, but also for Europe? “We plan to use various calculations and simulations to contribute to a blueprint for the widespread development of public truck charging infrastructure,” Plötz says. While researchers from Fraunhofer IAO scrutinized a single truck stop in detail, the team from Fraunhofer IAO zoomed out to analyze demand across the whole of Germany. Their findings surprised even the proj- ect manager himself. “Only about a third of trucks are involved in long-haul traffic at all, and of that amount, many of them don’t even travel such long distances that they would need megawatt charging infra- structure,” Plötz says. In fact, only about ten percent of Germany’s trucks will need megawatt charging in the long term. Still, he says, it is definitely a needed option. “It’s like with private cars. I generally charge my car at home. But for the few times I need to travel long distances on the highway when I’m going on vacation, the fast-charging infrastructure is fundamen- tal.” Plötz lays out his calculations: “By 2030, we’ll need at least 1,000 megawatt charging points at 142 locations in Ger- many if we don’t want drivers to have to wait more than five minutes for a free char- ger even during rush hour.” o t o h p k c o t s I / r e h p a r g o t o h P r o t a g i v A : o t o h P back to page 1 55

2 | 24 Fraunhofer magazine Ironclad assurance: Magnetic particles could help make bridges and overpasses safer. back to page 1 57 “I’m fascinated by the idea of giving materials a voice down the road.” Prof. Karl Mandel, Fraunhofer ISC o t o h p k c o t s i / s v e t n i k A , a p d / h u K d r a h n r e B : s o t o h P

FINLAND Ultra-accurate mapping of underwater structures precision laser-based measurements from underwater and aerial photo- graphs. Two compact sensor modules are used to gather data: a mobile, pres- sure-resistant underwater scanner and an ultra-lightweight drone scanner. This makes it possible to capture infor- mation on the structure of the sea floor right down to the millimeter, along with the water surface and depth and the shoreline, including the adjacent terrain. After being analyzed, the data is then combined into a point cloud forming a uniform system of geospatial coordinates. This creates a cohesive visualization of both system compo- nents. Two innovative LiDAR systems can now be used to survey offshore wind farms. In the CoLiBri project, scientists from the Fraunhofer Institute for Physical Measurement Techniques IPM are working with the Finnish Geospatial Research Institute (FGI) on a unique monitoring method that combines Future goals: keeping production up and running even in a pandemic. c i p o T T N A , ) 5 ( o t o h p k c o t s i e l l a / n o k - v e a h c e n , l e g n o d r u n o , 8 6 6 v o r a k a M , ) 2 ( g n g a m i I l a t n e m e l E : s o t o h P FRANCE AI makes robots more efficient Intelligent and versatile industrial robots that ensure interruption-free production, high levels of automation, and low energy consumption are the goal for GreenBotAI, a Franco-German project led by the Fraunhofer Institute for Machine Tools and Forming Tech- nology IWU. The researchers are work- ing on AI-based programming that allows the robots to autonomously sense environmental conditions, adjust to production requirements, handle complex tasks spontaneously, and identify errors. On the technical side, GreenBotAI is focusing on reducing response and latency times, optimized path planning, and execution of tasks on the fly, meaning while the robot is still moving. The aim is to harness AI solutions that rely on reduced data and faster gripping motions to signifi- cantly reduce energy consumption. A 25 percent reduction has already been achieved, with 50 percent as a target. 2 | 24 Fraunhofer magazine The Asian tiger mosquito alone can transmit 20 different viruses that present a risk to human health. EUROPE Preventing epidemics How high is the risk of new zoonoses, meaning infectious diseases transmit- ted to humans by animals? Researchers from the Fraunhofer Institute for Cell Therapy and Immunology IZI are work- ing with an interdisciplinary team of researchers to pursue that question in the EU’s ZOE project. Their goal is to identify risks early on and prevent epi- demics. To achieve that, the scientists from Europe and Latin America are studying various factors, including bio- diversity in forested areas with varying levels of human impact. They are using satellite images and field research to map landscape features and survey the animal and plant species found there. They are also collecting information on the distribution of potentially danger- ous microorganisms by testing com- mon vectors for zoonotic pathogens, like rodents, ticks, and mosquitoes, for bacteria and viruses. Fraunhofer IZI is developing analytical methods that can be used to test these samples for the relevant antibodies, comprehen- sively and with high throughput. back to page 1 59

2 | 24 Fraunhofer magazine “Working in artificial light for eight hours is suboptimal, both physiologically and psychologically.” Dr. Jan de Boer, Fraunhofer IBP s e g a m i s u i t i r u a m / 1 6 d n e t s e W / n o s f f e s o J : o t o h P — More natural light Video of the technology demonstration at a school in Krefeld www.youtube.com/ watch?v=2D6Zr9Pwv6s back to page 1 61

2 | 24 Fraunhofer magazine Inspiration for science: Geckos can cling to even panes of glass, thanks to millions of ultra-fine hairs on their feet. The adhesive force is many times greater than the reptiles’ weight. o t o h p k c o t s i i e d e b / n w o t r o N i a h c n a D , y r t m D n i l t e P : o t o h P back to page 1 63

2 | 24 Fraunhofer magazine of energy, minimizing environmental impact,” explains Dr. Clemens Kuhn, who has been the managing director at ALOtec Dresden since 2021. “These meth- ods allow us to extend the service life of components that are exposed to heavy wear and strain and offer sustainable solutions by repairing and reusing old or defective parts.” Fraunhofer IWS has worked with ALO- tec to further develop and refine existing laser processing methods. Laser hardening with thermal field control based on the LASSY dynamic beam shaping system is one example: The goal here was to guide a laser beam with a long focal length and fixed round or rectangular focus over a scanning mirror system to be able to harden components with even the most H b m G n e d s e r D c e t O L A : o t o h P “We gather informa- tion and ideas from real-world practice and approach Fraunhofer with topics and require- ments from industry and manufacturing.” Dr. Clemens Kuhn, ALOtec Dresden GmbH Contract automotive manufacturing: laser wire cladding (ALOwire) on a pressing tool. complex geometries, such as freeform sur- faces, case corners, or tapered cutting edges. The Efaqs pyrometer developed at Fraunhofer IWS or a special thermal imag- ing camera (Emaqs) can be used to deter- mine the exact temperature distribution at the surface, all without touching it. Equipped with both systems, the actual thermal field controller can then adjust the laser output accordingly, compensat- ing for temperature discrepancies caused by the geometry. “Our partnership with Fraunhofer IWS is not only shaped by joint projects, but in general by lively dialogue,” Kuhn says. “We gather information and ideas from real- world practice and approach Fraunhofer with topics and requirements from indus- try and manufacturing.” back to page 1 65

2 | 24 Fraunhofer magazine C an’t school be a little bit more like TikTok? That might sound like a teenager’s plaintive remark, but it is also a good encapsulation of what non- profit start-up DigitalSchoolStory (DSS) has set out to do. In DSS projects, schoolkids turn selected pieces of learning content into video clips in social media format, working as a team and with support from their idols on platforms like Instagram and YouTube. Goethe on TikTok instead of on paper? To Boomers, that probably sounds infantilizing. But the DSS learning method is anything but a silly game. It is intended to strengthen the soft skills that have previously been neglected in edu- cational assessments such as the PISA study, but will be essential to professional success as working environments become increasingly digital and automated. To make these skills measurable, thereby accelerating their implementa- tion in school curricula, researchers from the Fraunhofer Institute for Applied Information Technology FIT have now developed a new testing method. After all, factual knowledge alone is no longer enough in the world of the 21st century, which is shaped by what are known as the “VUCA” factors: volatility, uncertainty, com- plexity, and ambiguity. “This world no longer rewards us solely for what we know — Google already knows everything anyway. It rewards us for what we can do with what we know,” education researcher and OECD director Andreas Schleicher explains in the OECD Learning Compass 2030. Rethinking the ideal education with the “4 Cs” The Partnership for 21st Century Learning (P21), an American nonprofit, has identified four core competencies for coping with and shaping the world’s growing complexity: creativ- ity and innovation, critical thinking and problem solving, collaboration, and communication. So, instead of viewing education primarily as imparting knowledge that can be retrieved on demand, the DSS approach calls for students not only to develop the knowledge themselves, but then prepare it afterward in such a way that others understand the issue as well. Anyone who has ever tried to turn complex matters into a coherent story and explain them understandably in a 90-second clip knows that it’s not just a silly game. The PISA study regularly measures the performance of students worldwide in the base skills of reading, mathe- matics, and science. But what about core competencies for the 21st century? “Until now, there has been no measuring tool for capturing information on the 4 Cs in the Ger- man-speaking countries,” explains Gülsah Keskin, a psy- chologist and the project manager at Fraunhofer FIT. But that information is needed, since as Keskin notes, “A teach- ing concept has to be empirically proven effective first before the chances improve that it will achieve greater visibility in terms of education policy.” The measuring tool Keskin developed in cooperation with DSS encompasses the 4 Cs along with media literacy as an additional skill (dubbed the “4C plus” model). But unlike PISA, it does not test students’ knowledge. There are 25 questions, with five to eight items per competency, asking students to rate themselves on a scale from one to five. The students’ teacher also completes one survey per student, so the self-assessments are supplemented by an external viewpoint. The project group from Fraunhofer FIT used the tool at several schools before and after the DSS project. They found that educators are seeing positive change in the competen- cies of creativity and innovation, critical thinking and problem solving, and media literacy in particular, even if students themselves do not perceive these changes quite as sharply. Regular instruction alone made no significant difference to the 4 Cs. Learning according to the “TikTok principle” works, DigitalSchoolStory concludes: Co-creative development of video formats strengthens both media skills and critical thinking. Keskin, the project manager, also interprets the study’s results as encouragement to continue measuring the “4C plus” factors and developing innovative digital education concepts. She hopes surveys of core competencies will soon add a subjective component of skills assessment to the objective test of knowledge conducted as part of the PISA study to provide effective impetus for educating the young generation. Learning for life, with the “TikTok principle” Writing in the year 62 AD, the Roman philosopher Seneca was already critical of learning not for life, but for school: What was being taught in schools, he wrote pointedly, did not help students “to live correctly, but at most to speak like educated people.” His criticism is still cogent today. In her day-to-day life, Keskin notes time and again “that each of the five core competencies is important to professional success.” Ideally, some elements of these core competencies will show up early on, in initial interviews with applicants: “Anyone can learn quickly how certain systems work. But problem-oriented thinking, willingness to engage in life- long learning, and constructive collaboration with others across different cultures can’t be taught in a two-hour training course.” Incorporating the “4C plus” aspects into the education students receive in school, and potentially into vocational training as well, is something she views as important — so that the next generation learns not just for school, but actually for life. back to page 1 67 s e g a m i s u i t i r u a m / s e g a m I n a v a C : o t o h P

2 | 24 Fraunhofer magazine “About 75 percent of the genes that can cause disease in humans are also present in caterpillars.” Anton Windfelder, Fraunhofer IME o t o h p k c o t S i / n a g o r G W z i L : o t o h P A pest in agriculture, a handy helper for researchers: the tobacco hornworm. back to page 1 69

2 | 24 Fraunhofer magazine Rock-solid, yet sensitive: Follow-up surgery and expensive and time-consuming long-term treat- ment often follow a bone break. transferring it to the defect. And yet, conventional treatment methods reach their limits when the bone defect is large (5 cm or more) or infected. This is because it is difficult to hold the soft bone substance in place at the site of the defect to ensure proper healing, and because it may also be nec- essary to treat a local infection at the same time. This is where SCABAEGO comes in. “Our compos- ite material combines polycaprolactone, a biode- gradable polymer, with bioactive glass,” explains Dr. Kai Borcherding, head of the medical technol- ogy and life sciences business unit at Fraunhofer IFAM. Project partner BellaSeno uses this material to 3D print a custom-made supporting structure Up to ten percent of bone fractures do not heal properly, resulting in segmental defects. called a scaffold for the bone fracture site. The data used to shape the individual scaffold comes from computed tomography (CT) mapping of the broken bone. Dr. Tobias Grossner, senior physician and head of experimental trauma surgery at Heidelberg University Hospital, explains the new method’s benefits: “Surgery is performed to take bone sub- stance from the iliac crest or the medullary space inside the long bones of the body and then trans- ferred to where it is needed at the site of the o t o h p k c o t s i / n a h k g n a : o t o h P fracture. The scaffold, which has a mesh-like structure, holds the bone transplant material in place so new bone can form.” Unlike in previous methods, this minimizes the risk that the transplanted bone marrow will move out of place. It also helps make certain vas- cularization occurs undisturbed, so the break can heal cleanly. The bioactive glass inhibits the growth of any bacteria that may be present. Lowering the risk of infection The combination of polycaprolactone (PCL) and bioactive glass has further benefits. For one thing, the material transforms into a substance very similar to bone inside the body, and the bioac- tive glass also helps fight the risk of infection. Borcherding: “Our initial tests showed that the biological activity of the composite is right in the target range for inhibiting bacterial growth. A 4-log, or 99.99 percent, reduction in MRSA (methicillin-resistant Staphylococcus aureus) was demonstrated on the composite. This antibiot- ic-resistant bacterium is responsible for infections that are difficult to treat. This means the result is impressive in terms of both protecting the surface of the implant and reducing the risk of infection. ” The SCABAEGO research team is currently working with Heidelberg University Hospital to further refine the method. At the same time, the team is also optimizing the makeup of the com- posite material, particularly the percentage of glass. “Our goal is to leverage the biologically positive characteristics of glass as much as possible while maintaining the core strength of the scaffold,” says Borcherding. back to page 1 71

2 | 24 Fraunhofer magazine E ven legendary players like Messi and Ney- mar didn’t stand a chance against it: The RoboKeeper, from the Fraunhofer Institute for Material Flow and Logistics IML, uses 3D image processing, control technology, and algorithms to stop almost every ball. The robot, which looks like a life-sized goal keeper figure, was developed during the 2006 World Cup in Germany. Since then, it has been used at various events worldwide and has undergone ongoing optimization. The latest version came out right in time for the 2024 UEFA European Championship. These days, with artificial intelligence (AI) all the rage, the robot goalkeeper might not seem that impressive at first glance. Two cameras analyze the ball’s trajectory as it approaches the goal, and a motor sets the goalie in motion. All with no AI at all. But on closer inspection, it is clear just how cleverly designed the mechanisms behind the RoboKeeper are. “AI wouldn’t be smart enough for our goalie,” explains engi- neer Thomas Albrecht, head of driverless trans- portation systems at Fraunhofer I M L . “It would probably slow it down and make it more expensive.” Faster than a Formula 1 race car The goalkeeper figure is attached to an assembly com- prising an efficient and dynamic motor-drive combination with high power density. The drive, the motor controls, and the two gigabit color cameras are connected to a computer running 3D image processing software. All of the components — motor, cameras, and software — work at the highest level. After all, the RoboKeeper has to be able to stand up to the likes of Messi and Neymar. Just 50 milliseconds after the ball is kicked, the system knows where it will hit the goal. At a shot speed of 100 kilometers per hour, the ball has already traveled 1.5 meters by then. Immediately after it is launched, the cameras capture it at a rate of 90 frames per second (FPS). The image processing software then calculates a parabola describing the ball’s trajectory, and the system shows the keeper where the ball will hit. A drive with engine power of 21 kilowatts (about 28.55 HP) accelerates and brakes the figure at 20 times the acceleration due to gravity, or 17 times faster than a Formula 1 race car. The tips of the figure’s fingers reach a maximum speed of 53 kilometers per second in the process. In use worldwide and (almost) unbeatable All this makes it no wonder the RoboKeeper is a hot export these days. There are 44 of them in use worldwide now, marketed by sports marketing partner 4attention. The software in particular has undergone continuous improvement in recent years. But hardware components such as the camera, motor, and computer have also been replaced by advanced, higher-performance devices. The most recent upgrade is especially exciting, since even the RoboKeeper is not infallible: “Balls can reach the goal if the shot is really hard or hits the top corners because the RoboKeeper can’t reach them with its dimen- sions,” Albrecht says. Shots from a distance of ten meters, aimed at up to 100 kilome- ters per second straight at the left or right corner, are the hardest for the keeper to catch. The researchers at Fraunhofer IML just recently developed a ball retrieval robot that automatically brings the ball back to the player in these cases. Although the RoboKeeper is a real challenge even for prac- ticed players, Albrecht does not think using it to train the German national team would be very fruitful: “When our players practice shooting targeted goals, it just makes sense for the goalie to train with them.” Going head to head against top scorers builds the expe- rience that world-class goalies like Neuer need — which will always give them an edge over the RoboKeeper. — Video Messi and Neymar put the RoboKeeper to the test in Barcelona. www.youtube.com/watch?v=gp23q8VAi5E back to page 1 73 a p d / s r e t u e R / h c a b n e f f a f P i a K , n o i t n e t t a 4 / h c i r l U m m T : s o t o h P i

2 | 24 Fraunhofer magazine “We’re working on a whole fleet of mini, micro, and nano robots. This new technology opens up a huge range of possibilities.” Dr. Anna Christin Bakenecker, Fraunhofer IMTE Variable in shape, size, and material depending on where they are used in the body: smart transporters from Fraunhofer IMTE. method, you never know just how hot the tumor actually gets.” The team of researchers from Fraun- hofer IMTE has spent three years working closely with the Lübeck campus of Uni- versity Hospital Schleswig-Holstein on the submarines, which were initially about three millimeters in size — making them too large for many medical applications. In the meantime, sophisticated 3D print- ing technology has allowed the team at Fraunhofer IMTE to shrink them down to 400 micrometers. Unlike the older model, which looked more like corkscrew pasta, the new one is more like a screw. Bake- necker explains: “When you make some- thing much smaller, you need a different shape for the propulsion system for phys- ical reasons. The older sub had a forward propulsion system like a ship, while the new one “spirals” forward. While the miniaturization process has been a success, Bakenecker and her team are still tinkering with the perfect pro- duction material. The scientists are test- ing various hydrogels, which are gels made from polymers that can bind water. “There’s a wide range of hydrogels that have really exciting properties, are easily tolerated, and can be used in a whole spectrum of applications,” Bakenecker explains. They could also be printed with the drugs built right in, for example. “Right now, I’m working with a hydrogel that dissolves as soon as the pH value changes, which happens near a tumor. So, the mini sub would break down at its destination, releasing the therapeutic agent.” The iron oxide coating can also be broken down by the body, so it is tolerated well. To get active ingredients to hard-to-reach areas of the body, such as joints, Bake- necker plans to make the transporters even smaller: “We can do without the submarine as a vehicle and simply use the iron oxide nanoparticles, which the drugs bind to. You do need a huge quantity of particles to get to an effective dose, of course. And then you can picture them zooming through the body like a swarm of bees, controlled by our magnetic field.” The nano-transporters could be used to ensure that anti-inflam- matory drugs spread through injured joints more effectively. “Synovial fluid, the fluid inside the joints, has high viscosity, so medications don’t spread as easily there,” Bakenecker explains. The larger miniature submarines are a better choice for other applications, such as if a larger volume of an active ingredi- ent needs to be transported or repairs are required for a life-threatening aneurysm — an abnormal bulge that forms in a defec- tive arterial wall. Blood can collect there, and there is a risk of bursting. “In that case, we wouldn’t use our submarine to trans- port a drug. Instead, we would steer it to the bulge and close it. The blood would then clot around the foreign body, holding it in place,” Bakenecker says. The idea is to create a permanent solution, stopping the blood from flowing continuously into the bulge and pressing against the weak- ened spot. This form of the boat would need not to dissolve, but instead remain stable. “There are many different potential sce- narios where our tiny subs could be used. The size and production materials could be adjusted depending on the intended purpose,” Bakenecker explains. “So, we’re working on a whole fleet of mini, micro, and nano robots. This new technology opens up a huge range of possibilities.” back to page 1 75 y r a r b i L o t o h P e c n e i c S / s n o i s i V k c i b b a H r o t c i V : o t o h P

Joseph von Fraunhofer Prize 2024 Research prizes Since 1978, the Fraunhofer- Gesellschaft has awarded prizes to its employees for outstanding scientific achievements. 2 | 24 Fraunhofer magazine The innovative PLA material is at least 80 percent bio-based. is covalently linked to PLA chain segments at both ends,” explains Rodríguez. The result is a novel, flexible PLA material that does not require migrating plasticizers and, unlike LDPE, is at least 80 percent bio-based. “In the long term, we might be able to increase this proportion to almost 100 percent,” Gomoll explains. “In addition, our material can be pro- duced cost-efficiently from commercially available raw materials in a simple synthesis process. This process does not require large-volume synthesis plants but can be implemented locally by medium-sized companies as a continuously operated process. Finally, the new PLA material can also be processed into plastic films using conventional processing plants in a similar way to LDPE — and it can be chemically recycled with considerably less energy input than LDPE,” Gomoll continues. Gomoll, Rodríguez, and Lieske have been awarded the Joseph von Fraunhofer Prize for 2024 for developing this flexible and recyclable PLA material. Successful commercial implementation The sustainable material developed by Fraunhofer IAP is the first of its kind — a full substitute for LDPE in flexible film applications in terms of material parameters. This prompted a company called Polymer-Group to commer- cialize the new material. In 2023, SoBiCo GmbH, a subsid- iary of Polymer-Group, commissioned a production plant for the new PLA block copolymers. It produces 2,000 tons of the new bioplastics per year under the name Plactid®. In the long term, it is set to produce 10,000 tons of the new flexible PLA material each year. The material will represent an important contribution to making plastic packaging materials more sustainable. In addition to flexible packaging films, the new material might also tap into completely new use cases in fields such as the automotive sector, the textile industry and additive manufacturing. back to page 1 i k s i w o r e z c n a B r t o P / r e f o h n u a r F : s o t o h p l l A 77

Patented technology with a bright future The MorphoColor® technology developed at Fraunhofer ISE was patented in 2017 as a plug-in solution that can be used with all standard commercially available solar technologies as well as those foreseeable in the future, plus it can be manufactured industrially at low cost. Cell and panel technologies with a uniform appearance are an especially good fit. These include rear contact solar cells and the matrix shingle technology also developed at Fraunhofer ISE. Normally the tile-sized photovoltaic cells are soldered together. To keep them from showing through the colored protective glass like checkerboard squares, the researchers at Fraunhofer ISE developed an assembly method that evokes a masonry effect. “In matrix shingle technology, the conductive adhesive bonding of the solar cells eliminates the need for reflective metallic connectors between the cells, creating a homogeneous appearance. That means the solar cell technology remains completely invisible behind the colored layer. And that in turn enables aesthetically pleasing and complete visual integration into facades or roofs,” Höhn explains. The MorphoColor® trademark is already registered in the EU, Switzerland, China, the United States, Japan, and 2 | 24 Fraunhofer magazine “A morpho butterfly’s wings give an impression of color not through colored pigments, but rather thanks to a visual effect.” Dr. Thomas Kroyer, Fraunhofer ISE South Korea. A license was granted in 2023 to Switzer- land-based Megasol Energie AG, a leading European producer of solar panels and in-roof and facade installa- tion systems that is currently establishing the Morpho- Color® technology on the market. Integration of solar panels into vehicles is another promising field of devel- opment. Fraunhofer ISE presented glass car roofs and hoods with integrated MorphoColor® solar panels at the IAA automotive fair, generating great interest from Ger- man carmakers. : s o t o F Dr. Thomas Kroyer (left), Dr. Oliver Höhn (center) and Andreas Wessels are working to increase acceptance of solar panels. back to page 1 79

2 | 24 Fraunhofer magazine sand or gravel. In process engineering, MESHFREE has helped companies optimize process parameters when working with molten glass and using plastic parts and to boost the efficiency of water turbines by simulating aspects such as the influence of air on the flow and the abrasion of blades due to sand particles. Fundamentally, this method can be used anywhere that a substitute is needed for measurements or experiments, or where these methods do not work well or not at all. Michel sums up: “We’re not fixated on the traditional use cases for computational fluid dynamics. MESHFREE can do much more. We deliberately kept the tool more general.” “Back then, there was no way to quickly verify the safety of new developments in this field aside from costly real-world crash tests.” Dr. Jörg Kuhnert, Fraunhofer ITWM Adjusting flexibly to movement: the cloud of numerical points used in MESHFREE. MESHFREE: a substitute for real-world tests “Our very first task within the project team, over 20 years ago, was to simulate how an airbag would deploy in a vehicle collision,” says Dr. Jörg Kuhnert, who does research with his colleague Dr. Isabel Michel at Fraun- hofer ITWM. “Back then, there was no way to quickly verify the safety of new developments in this field aside from costly real-world crash tests.” That is because the more objects move and interact with each other in a given situation — in the case of a rear-end collision, for example, that means the car itself, the people inside, and the airbag as it deploys — the more difficult it becomes to visualize them reliably and at reasonable levels of time and effort using traditional simulation methods. Based on Kuhnert’s dissertation, the team — joined in 2012 by Michel, who specializes in Pelton turbines — developed the innovative mesh-free approach to meet this challenge at Fraunhofer ITWM. The new approach makes it possible to visualize highly complex and dynamic situations, in some cases for the very first time. All of the team’s research findings since then have gone into the MESHFREE software tool, which is unique: No other simulation tool at the international level makes it possi- ble to use the generalized finite difference method (GFDM) for industrial purposes. Flexible method for dynamic processes Traditionally, simulations use the finite element method, in which engineers design a mesh that fits the relevant geometry and use it as a basis for calculating the changes in each individual element. The initial pro- cess of setting up the mesh structure is already highly time-consuming, and frequent adjustments are required during the simulation as well. The MESHFREE software, by contrast, combines the generalized finite difference method, which it uses to solve the conservation equa- tions of mass, momentum and energy, with efficient algorithms for solving linear systems of equations. These were developed in cooperation with the Fraunhofer Institute for Algorithms and Scientific Computing SCAI and offer a huge advantage sincethe cloud of numerical points that is used can adapt flexibly to moving geome- tries. This eliminates the need for laborious subsequent corrections in the computational mesh. Kuhnert and Michel are the recipients of the Joseph von Fraunhofer Prize for 2024 for their development, which can replace real-world testing. The award-winning method can be used for a wide spectrum of applications. One current area of focus is the automotive sector. In addition to airbag simulation, the researchers have assisted their numerous industry part- ners in a variety of ways so far, including by modeling driving through water or how vehicles will behave on back to page 1 81

2 | 24 Fraunhofer magazine University Hospital Essen, the new approach was compared against the previous diagnostic standard, and its diag- nostic benefit was evaluated by bodies made up of inde- pendent experts. For their part, Stevens and his colleague Dr. Silke Grumaz, now Chief Scientific Officer at Noscendo GmbH, had worked on the method’s foundations during their time at Fraunhofer IGB, Stevens in bioinformatics and Grumaz in molecular biology. By founding Noscendo GmbH, they created a channel for hospitals to submit samples for rapid analysis at any time. Grumaz comments: “We generally get results within 24 hours after the blood sample arrives at our lab. If a hospital doesn’t use the method itself, the logistics can take another 12 hours. In most cases, that’s still faster than any blood culture.” Dr. Kai Sohn, Head of the In-vitro Diagnostics depart- ment at Fraunhofer IGB, stresses how happy everyone on the team is at their shared success: “Our method could only have been established and successfully brought right to the patient’s bedside through partnership between Fraunhofer, leading clinical networks, and Noscendo GmbH.” A milestone with more to come The partners do not see the award as marking the conclu- sion of their work. “Right now, we’re moving into pedi- atric intensive care. Fast, reliable diagnosis is critically important in this field, since the amount of blood that can be taken from the littlest patients is very small,” Bren- ner explains. The prize winners also plan to apply their method to other diseases, such as localized infections that are difficult to diagnose. They are also working to apply the method to other bodily fluids and tissue samples, expanding it beyond blood samples alone. DNA fragments in the blood help to identify pathogens. Stifterverband Science Prize 2024 For more than 20 years, Stifter- verband and the Fraunhofer- Gesellschaft have been recog- nizing joint applied research projects of particular excellence that Fraunhofer institutes are working on in collaboration with industry and/or other research organizations. gens can seldom be “caught in the act,” the scientists instead study the clues they leave behind at the scene — fragments of their genetic information in the blood. The researchers use a fully automated process to isolate the DNA fragments and then sequence them with high throughput. If they find fragments of a non-human origin, the specialists compare them against a specially developed database containing the genomes of bacteria, viruses, fungi, and other pathogens. Proven in clinical practice Numerous clinical studies show that this method is highly reliable and accurate and provides healthcare professionals with valid results. The pathogen that is causing the disease can be identified in up to 70 percent of patients studied. “Our diagnostic method has helped over 6,000 patients in the past four years alone,” says Dr. Philip Stevens, a bioinformatics scientist and CEO and co-founder of Noscendo GmbH. “Patients are able to leave the hospital much faster and have fewer long-term effects. That also eases the burden on hospitals and health insurers.” Outstanding collaboration This success is the product of more than ten years of interdisciplinary cooperation. The method itself is a three-step process involving optimum sample prepara- tion, high-throughput next-generation sequencing (NGS), and bioinformatic analysis via diagnostic algorithms. Initially developed at Fraunhofer IGB, this method is one building block of the new approach. Clinical validation required close collaboration with leading medical centers. The experts there provided suitable samples and patient data, but that was not all. Under the leadership of Prof. Thorsten Brenner from back to page 1 83

2 | 24 Fraunhofer magazine L ooking at the term HypS²tar 3b, a person could certainly be forgiven for thinking it is an ultra-secure password. In fact, it stands for a tough-to-crack task instead: detecting and tracking hyper- sonic objects. The war in Ukraine has really brought home to many people just how dangerous hypersonic weapons are — and how hard it is to defend against their destructive capabilities. Unlike objects that move at the speed of sound (343 meters per second) or slower, these objects travel at about Mach 5, at speeds greater than 1,700 meters per second. This presents a huge challenge for conven- tional radar systems. “At speeds like these, radar echoes can be too weak, blurred, or too far apart when they show up on the screen. That makes it harder to track these objects,” says René Petervari from the Fraunhofer Institute for High Frequency Physics and Radar Techniques FHR. Wind tunnel experiments can help to better understand the complex physics involved and devise solutions. In the inter- disciplinary Hypersonic Signature Studies for Radar (HypS²tar) research initiative, Petervari is working with experts from the French-German Research Institute of Saint- Louis (ISL) in Saint-Louis, France, and the German Aerospace Center (DLR) Institute of Aerodynamics and Flow Technology in Göttingen and Braunschweig, Germany, to further understand the radar echoes created by hypersonic objects. The Fraunhofer researchers’ job is to refine the radar sys- tems and optimize the algorithms. The radar signatures created in the wind tunnel help with this, along with detailed, true-to-life aerodynamics and radar simulations. “We started back in 2021 with a sphere in the wind tunnel, and then refined the results.” René Petervari, Fraunhofer FHR But how do you build a wind tunnel in which the air streams past the objects at more than five times the speed of sound? Petervari explains the principle: the researchers use a type of wind tun- nel known as a shock tube. A gas like hydrogen or helium is compressed to a pressure of several hundred bar. The pressure causes a metal diaphragm to rupture along special perforations. The high-energy gas this releases is then accelerated to hypersonic speed via a de Laval nozzle, a development also used in rocket technology. “We started back in 2021 with a sphere in the wind tunnel, and then we moved on to a cone and continued refining the results in stages,” the Fraunhofer expert recalls. “Right now, we’re working with the HypS²tar 3b, a glider-shaped flying object 1.5 meters in size. Its glider-like shape and metallized surface make it a realistic test object,” Petervari says. The radar system the team of researchers uses is known as software-defined radar. Fraunhofer FHR has a wealth of expertise and experience with this technology. The systems have very few analog com- ponents, relying on software modules instead. The software algorithms are adjusted and refined in an iterative process as the wind tunnel experiments progress. They allow for a better focus on the radar echoes while preventing reductions in range and malfunctions during automatic tracking. Owing to limits in processing capacity, conventional radar systems had previously relied on approximations, but they reach their limits as object speed increases. The Fraunhofer researchers have developed a better understanding of the physics involved through their experiments and are now focusing on powerful electronics, state-of-the-art radar systems, and advanced software. This eliminates the need for these kinds of approximations and enables greater accuracy in calculating an object’s speed and trajectory. For their project, the researchers at Fraunhofer FHR can also rely on the resources of the Fraunhofer Segment for Defense and Security V VS, in which twelve Fraunhofer institutes develop technologies that contribute to the secu- rity of people, society and the state. Fraunhofer V VS Managing Director Caroline Schweitzer comments: “Our experts have been conducting interdis- ciplinary research on detecting and repelling hypersonic threats for years. This will be strategically important in the future to protect high-value targets within our critical infrastructure.” R L D / R H F r e f o h n u a r F , L S I / R H F r e f o h n u a r F : s o t o h P The flying object used for testing is 1.5 meters long. back to page 1 85

Fraunhofer on the road Berlin Düsseldorf Nuremberg Munich 2 | 24 Fraunhofer magazine Düsseldorf November 11–14, 2024 MEDICA The leading international trade show for medical technology Düsseldorf November 11–14, 2024 COMPAMED The leading international trade show for medical technology suppliers Munich November 12–15, 2024 Electronica The leading international trade show and conference for electronics — 75 years of Fraunhofer Berlin September 24–27, 2024 Innotrans International trade show for transport technology Berlin October 15–17, 2024 Smart Country Convention (SCCON) Understand and shape future solutions for digital administration, connected cities, and mobile spaces Nuremberg October 22–24, 2024 It-sa Trade show and congress for IT security Fraunhofer magazine The magazine for people shaping the future Would you like to get the Fraunhofer magazine in your mailbox as soon as it comes out — for free? Order it online directly at https://s.fhg.de/of back to page 1 87 2 | 24Deepfakes & disinformation How research helps fight manipulationDr. Marius Mohr, Fraunhofer IGBFraunhofer start-upsFrom one-person company to success with laser technology Bring on the water! Improving management of this vital resource“We take the situation seriously!”Interview with Nancy Faeser, the German Federal Minister of the Interior“Cutting-edge research is the driver of innovations”Interview with Hendrik Wüst, minister-president and rising star in the CDU party1 | 24“We need a culture of openness”Siemens CEO Roland BuschHarnessing pollution for goodCO2Rethinking masonry:Dr. Michael ProkeinFraunhofer: a success story through timeDr. Georg Umlauf, Fraunhofer IGB, points the way toward clean water.Ways forward for water, industry and the world PFAS: The poison of the century4 | 23“I feel like Krampus” An interview with German finance minister Christian Lindner2024 — Time to lighten up Trends in lightweight construction“Pragmatism trumps the sledgehammer approach”An impassioned plea from Dr. Martin Brudermüller, BASF SE